EMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatments

In this paper, we follow up with our preliminary biological studies that showed that Repeated electromagnetic field stimulation (REMFS) decreased the toxic amyloid-beta (Aβ) levels, which is considered to be the cause of Alzheimer’s disease (AD). The REMFS parameters of these exposures were a frequency of 64 MHz and a Specific absorption rate (SAR) of 0.4 to 0.9 W/Kg in primary human neuronal cultures. In this work, an electromagnetic field (EMF) model was simulated using high-frequency simulation system (HFSS/EMPro) software. Our goal was to achieve the EM parameters (EMF Frequency and SAR) required to decrease the toxic Aβ levels in our biological studies in a simulated human head. The simulations performed here will potentially lead to the successful development of an exposure system to treat Alzheimer’s disease patients. A popular VFH (very high frequency) patch microstrip antenna system was considered in the study. The selection was based on simple and easy construction and appropriateness to the VHF applications. The evaluation of the SAR and temperature distribution on the various head layers, including skin, fat, dura, the cerebrospinal (CSF), and grey matter, brain tissues, were determined for efficacy SAR and safety temperature increase on a simulated human head. Based on a current pulse of 1 A peak current fed to the antenna feeder, a maximum SAR of 0.6 W/Kg was achieved. A range of 0.4 to 0.6 SAR was observed over the various layers of the simulated human head. The initial design of the antenna indicated an antenna size in the order of 1 m in length and width, suggesting a stationary practical model for AD therapy. Future direction is given for wearable antenna and exposure system, featuring high efficiency and patient comfort.


INTRODUCTION
Alzheimer's disease (AD) had been spreading worldwide with little development in treatment. The number of people living with Alzheimer's disease (AD) and other dementias worldwide was estimated at 46 million in 2015, with an estimated prevalence reaching 131 million in 2050 [1]. Research efforts to slow down, or stop the disease, will potentially impact the healthcare system and the global economy. AD is a complex and heterogeneous disorder. The drugs approved by the U.S. Food and Drug Administration (FDA) for the treatment of AD do not stop the progression of the disease [2]. Research efforts have also examined strategies with antibody treatment against Aβ and alternative modalities to slow down the disease progress [3,4]. Given the poor tolerability of pharmaceuticals in the treatment of AD, there is a growing interest to explore other potential noninvasive mechanisms including EMF exposures. A recent clinical trial of electromagnetic exposure (915 MHz) to AD patients found no significant side effects or physiologic changes [5]. Active research in the use of noninvasive brain stimulation as a potential therapy for AD has included several pilot studies and small clinical trials that have highlighted the potential for neuroenhancement and improvement in cognitive function in healthy individuals via noninvasive brain stimulation (NBS) [6]. Mechanism of action, efficacy, and reproducibility [7][8][9] were issues to be further addressed in future research. The EMF clinical trial mentioned above used 915 MHz with a high frequency is probably not effective in the sense that radiation does not reach important deep tissues of a human head (only 3 to 4 cm tissue penetration depth). In our proposed efforts in this study, we explore the use of repeated electromagnetic field stimulation (REFMS), as a non-invasive potential strategy to lower the Aβ peptide load observed in AD. REMFS uses a non-thermal mechanism to produce biological effects, this occurs at the molecular level and involves multitarget interactions between signaling pathways [10,11]. Computer simulations for EMF exposures at a frequency of 64 MHz and a SAR of 0.4 -0.9 W/Kg may establish a framework for safe human exposure [12][13][14]. Overall efforts to develop noninvasive therapeutic strategies point to the development of portable devices for AD treatment.
In this research work, the repeated electromagnetic field stimulation (REMFS) was found to be decreasing the toxic amyloid-beta (Aβ) levels [15], which is considered to be the cause of Alzheimer's disease (AD). HFSS was utilized to obtain the antenna parameters and the field distribution following the preliminary results reported in [15].

THE FIELD MODEL
The following field equations that are combined to determine the field distribution and the SAR values are given by Maxwell's equations combined with the heat equations over the various boundaries of the human head tissues. The solutions of the following equations via HFFS/EMPro give the field and SAR distribution over the human head tissues.
With the lossy media, considering the conductivity, σ, the power equation is given as [16,17]: The average power as function of the electric field, E, in lossy media is given by: where dv is the differential volume.
The dielectric loss in a material due to electric conductivity is given by: The microwave dissipated power term is considered as the source term in Fourier heat transfer equation [18]: ρC p ∂T / ∂t = k ∇ 2 T + P v (x, y, z, t) (8) where ρ is the mass density, and C p is the specific heat capacity.
The SAR may be evaluated by the equation: The change in thermal energy/temperature change is given by: q = mC p ∇T (10) The SAR is then can be calculated by ΔSAR = C p ΔT/Δt, where ΔT is the change in temperature related to change in SAR by a value of ΔSAR over time Δt.

ANTENNA STRUCTURE
Based on the 64 MHz radiation pattern, the dimensions of the patch antenna are given in the range of 1.07 m × 1.38 m. The Matlab estimation is based on the following equations: The width of the patch, w, is given by [19]: W = v 0 2f r 2 ε reff + 1 (11) where v 0 = speed of light, and f r is the desired frequency. The effective dielectric constant is given by [18]: where ε r = dielectric constant of the substrate; ε r,eff = effective dielectric constant: 1< ε r,eff < ε r .

SIMULATION RESULTS
HFSS/EMPro was used in the estimation of the scattering S 11 parameter, the Antenna SAR distribution with and without brain tissues, the E field, and SAR at the various layers of the simulated human head. The antenna device was estimated for a 64 MHz homogeneous pattern and 0.6 SAR in the brain simulation. Figure 1 gives the patch antenna structure. The scattering S 11 parameter is given in Figure 2, and the current pulse that fed the antenna is given in Figure 3.
The antenna E-field is given in Figure 4. With maximum field given in the x-direction reaching the simulated brain. The SAR distribution in the XY plane and the XZ plane are given in Figure 5(a) and Figure 5(b) respectively. As it can be seen the SAR ranges from 0.2 to 0.9 in the simulated brain tissue. The SAR value decreased as the power radiated decreased from the brain tissue out towards the skin. The SAR value was higher before the power was absorbed by the human head. Figure 6 shows that the simulated antenna provides SAR values that range from 2 to 9 W/kg before simulated human head absorbs the EMF energy.
The 64 MHZ radiating frequency was appropriate for the penetration depth needed to reach multiple layers until the brain tissue. With enough penetration depth, the current need to drive the antenna and to reach the required power is reasonably well. As it can be seen, the input power is sufficient to reach the required SAR. The 64 HMz is also appropriate for the medical applications since it is the same frequency used for the MRI imaging. The data with the big size patch antenna suggests a stationary practical model for the EMP device Alzheimer treatment. The matching impedance from the feeder to the antenna should be considered in order to optimize the power transmission into the head phantom.

CONCLUSION AND FUTURE WORK
In this work, we successfully used HFSS in estimating the SAR values at the various tissues of a simulated human head with a simple strip antenna. The size of the antenna was found to be in the meter range, suggesting a stationary EMR system to be used for AD therapy. A meander line antenna [20] may be a potential candidate for miniaturizing an antenna system in order to achieve a wearable comfortable system with manageable wearable devices. Figure 7 gives a proposed antenna for wearable device system in the helmet form. The system was initially simulated and the field distribution was given in Figure 7(b). The details of this antenna wearable system are reserved for future considerations.
An accurate human model is essential in wearable antenna design. The accuracy of the simulation may be enhanced by the Zubal anthropomorphic phantom where original X-ray CT images were reconstructed [21]. Figure 8 shows the head phantom under consideration for future work. Also, the accuracy of the simulation for individual patients can be enhanced using Digital Imaging and Communication in Medicine (DICOM) based anthropomorphic phantom voxel data [22]. The patch antenna structure.